2/12/2023 0 Comments Winnonlin trial download![]() ![]() Rosiglitazone was well tolerated by all patients, as judged by the Treatment Satisfaction Questionnaire for Medication. Results: There were no serious adverse events or cardiovascular complications. ![]() ![]() PK was assessed twice, after the initial dose and after attaining steady state, in a General Clinical Research Center. The primary goal was assessment of safety, tolerability, and pharmacokinetics (PK) of rosiglitazone.ĭesign, setting, participants, & measurements Eleven patients, including eight boys/men and three girls/women, with mean age 15 ± 6 yr and estimated GFR 131 ± 62 ml/min/1.73 m 2, received rosiglitazone, 3 mg/m 2/d for 16 wk. This paper presents the results of a Phase I clinical trial of rosiglitazone, a thiazolidinedione, that exerts antifibrotic effects in animal models of FSGS. ![]() Prevention of renal fibrosis represents a promising strategy to slow or halt kidney function decline. Background and objectives: Patients with primary focal segmental glomerulosclerosis (FSGS) who are resistant to standard therapy are at high risk for progressive chronic kidney disease. ![]()
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